Drugs in preclinical and early clinical development for the treatment of Chagas´ s disease: the current status

FKVS Torchelsen, AL Mazzeti… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Chagas disease is spreading faster than expected in different countries, and
little progress has been reported in the discovery of new drugs to combat Trypanosoma cruzi …

Evaluation of chimeric recombinant antigens for the serodiagnosis of Trypanosoma cruzi in dogs: a promising tool for Chagas disease surveillance

ND Fontes, FL Habib, LM Leony, NEM Freitas… - Parasites & …, 2024 - Springer
 Abstract Background Chagas disease (CD), a neglected parasitic disease caused by
Trypanosoma cruzi, poses a significant health threat in Latin America and has emerged …

Mammalian placental explants: A tool for studying host-parasite interactions and placental biology

C Castillo, C Díaz-Luján, A Liempi, R Fretes… - Placenta, 2024 - Elsevier
The placenta plays a critical role in host-pathogen interactions. Thus, ex vivo infection of
mammalian placental explants is an excellent and simple method to study the mechanisms …

[HTML][HTML] The Impact of Environmental and Housing Factors on the Distribution of Triatominae (Hemiptera, Reduviidae) in an Endemic Area of Chagas Disease in …

M Ortega-Caballero, MC Gonzalez-Vazquez… - Diseases, 2024 - mdpi.com
Background: Chagas disease (CD), a Neglected Tropical Disease caused by Trypanosoma
cruzi, affects millions of people in Latin America and the southern US and spreads …

Trypanosoma cruzi infection in black bears (Ursus americanus): A case report in a cub from California and serologic survey for exposure in wild black bears from …

R Hughes, R Francisco, K Garrett, K Willitts… - … : Regional Studies and …, 2024 - Elsevier
Trypanosoma cruzi is an important cause of disease and death in humans and dogs, and
although wildlife infections are common, less is known about disease manifestations. A 12 …

Neglected tropical diseases: tackling the challenges of a global world

A Rodrigues, G Santos-Gomes - Frontiers in Toxicology, 2024 - frontiersin.org
In today's interconnected world, the fight against neglected tropical diseases (NTDs)
presents both unique challenges and unprecedented opportunities. Despite significant …