Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

MYC, a major oncogenic transcription factor, regulates target genes involved in various
pathways such as cell proliferation, metabolism and immune evasion, playing a critical role …

Perturbations in transforming growth factor-β (TGF-β) signaling can lead to a plethora of
diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

In recent years, protein arginine methyltransferases (PRMTs) have emerged as new
members of a gene expression regulator family in eukaryotes, and are associated with …

Radioresistance is regarded as the main cause of local recurrence and distant metastasis in
non-small cell lung cancer. However, the underlying mechanisms of radioresistance …

MYC is a notorious oncogene in a vast network of malignancies, whereas liver‐specific
microRNA‐(miR‐) 122‐5p is downregulated in hepatocellular cancer (HCC). Here, we …

α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …

The protein arginine methyltransferases (PRMTs) are involved in such biological processes
as transcription regulation, DNA repair, RNA splicing, and signal transduction, etc. In this …

Recent comprehensive genomic studies including single-cell RNA sequencing and
characterization have revealed multiple processes by which protein-coding and noncoding …