Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid
metabolism due to deficient or absent lysosomal α-galactosidase A activity. FD is pan-ethnic …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

Background Fabry disease, an inherited lysosomal storage disorder, causes multi-organ
pathology resulting in substantial morbidity and a reduced life expectancy. Although Fabry …

Metabolome reflects the interplay of genome and exposome at molecular level and thus can
provide deep insights into the pathogenesis of a complex disease like major depression. To …

Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Fabry disease is an X-linked inherited condition due to the absence or reduction of α-
galactosidase activity in lysosomes, that results in accumulation of globotriaosylceramide …

Fabry disease is a frequent lysosomal storage disorder secondary to the deficiency of alpha-
galactosidase A enzyme. This X-linked genetic disease realizes progressive and systemic …

Summary Aims Patients with Fabry disease (FD) characteristically develop peripheral
neuropathy at an early age, with pain being a crucial symptom of underlying pathology …

Background Fabry disease is an inherited metabolic disorder characterized by progressive
lysosomal accumulation of lipids in a variety of cell types, including neural cells. Small …

Venglustat inhibits the enzymatic conversion of ceramide to glucosylceramide, reducing
available substrate for the synthesis of more complex glycosphingolipids. It offers a potential …