[HTML][HTML] Macrocyclic lactone resistance in Dirofilaria immitis: risks for prevention of heartworm disease

RK Prichard - International Journal for Parasitology, 2021 - Elsevier
Heartworm disease, caused by Dirofilaria immitis, can be lethal in dogs and cats. It is
transmitted by mosquitoes, and occurs in many parts of the world. Prevention relies on …

[HTML][HTML] An accessible alternative to melarsomine:“moxi-doxy” for treatment of adult heartworm infection in dogs

LS Jacobson, BA DiGangi - Frontiers in Veterinary Science, 2021 - frontiersin.org
Canine heartworm infection, caused by the filarial parasite Dirofilaria immitis, represents a
serious and expanding animal welfare concern that is expected to increase due to the …

[HTML][HTML] Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for …

K Kryda, RH Six, KF Walsh, SJ Holzmer, S Chapin… - Parasites & vectors, 2019 - Springer
Background Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal
cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety …

[HTML][HTML] Concern for Dirofilaria immitis and Macrocyclic Lactone Loss of Efficacy: Current Situation in the USA and Europe, and Future Scenarios

A Diakou, RK Prichard - Pathogens, 2021 - mdpi.com
Dirofilaria immitis infection is one of the most severe parasitic diseases in dogs. Prevention
is achieved by the administration of drugs containing macrocyclic lactones (MLs). These …

[HTML][HTML] Preventive efficacy of oral moxidectin at various doses and dosage regimens against macrocyclic lactone-resistant heartworm (Dirofilaria immitis) strains in …

TL McTier, RH Six, A Pullins, S Chapin, K Kryda… - Parasites & vectors, 2019 - Springer
Background Moxidectin has previously shown limited efficacy (≤ 44.4%) against confirmed
macrocyclic lactone (ML)-resistant Dirofilaria immitis strains at 3 µg/kg after single and …

[HTML][HTML] Heartworm adulticide treatment: a tropical perspective

F Dantas-Torres, J Ketzis, G Pérez Tort, AD Mihalca… - Parasites & vectors, 2023 - Springer
Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence
surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour …

Novel anti-Wolbachia drugs, a new approach in the treatment and prevention of veterinary filariasis?

JD Turner, AE Marriott, D Hong, P O'Neill, SA Ward… - Veterinary …, 2020 - Elsevier
Filarial nematodes are tissue-dwelling parasitic worms that can cause a range of disfiguring
pathologies in humans and potentially lethal infections of companion animals. The bacterial …

[HTML][HTML] Exploration of the sensitivity to macrocyclic lactones in the canine heartworm (Dirofilaria immitis) in Australia using phenotypic and genotypic approaches

RI Power, J Šlapeta - International Journal for Parasitology: Drugs and …, 2022 - Elsevier
Canine heartworm disease is a potentially deadly cardiopulmonary disease caused by the
mosquito-borne filarial nematode Dirofilaria immitis. In Australia, the administration of …

[HTML][HTML] Efficacy of semi-annual therapy of an extended-release injectable moxidectin suspension and oral doxycycline in Dirofilaria immitis naturally infected dogs

B Alberigi, JI Fernandes, JP Paiva… - Parasites & …, 2020 - Springer
Background Dirofilaria immitis is a life-threatening nematode spreading globally. Arsenical
treatment is currently recommended for removal of adult worms. However, arsenical …

[HTML][HTML] Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance

MD Savadelis, TL McTier, K Kryda, SJ Maeder… - Parasites & …, 2022 - Springer
Heartworm (Dirofilaria immitis) disease continues to increase and spread, remaining one of
the most important and pathogenic parasitic diseases of dogs, despite the regular use of …