Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Proteins, a type of natural biopolymer that possess many prominent merits, have been
widely utilized to engineer nanomedicine for fighting against cancer. Motivated by their ever …

Excess iron deposition in the brain often causes oxidative stress-related damage and
necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one …

Glioma is a fatal disease with limited treatment options and very short survival. Although
chemotherapy is one of the most important strategies in glioma treatment, it remains …

Ferritin, a ubiquitously expressed protein, has classically been considered the main iron
cellular storage molecule in the body. Owing to the ferroxidase activity of the H-subunit and …

Since its discovery more than 85 years ago, ferritin has principally been known as an iron
storage protein. However, new roles, beyond iron storage, are being uncovered. Novel …

Background The interactions between nanoparticles (NPs) and plasma proteins form a
protein corona around NPs after entering the biological environment, which provides new …

Glioma is one of the most common aggressive brain malignancies, but the treatment of
glioma is still far from satisfying. The efficiency of chemotherapy–the major choice of glioma …

Penetration of the blood–brain barrier (BBB) and the blood–brain tumor barrier (BBTB)
remains a significant challenge for the delivery of drugs in the treatment of glioma …

Breast cancer is prevalent and diverse with significantly high incidence and mortality rates.
Curcumin (Cur), a polyphenol component of turmeric, has been widely recognized as having …