Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

The DNA mismatch repair (MMR) system is nec-essary for the maintenance of genomic
stability. In a broad sense, all main functions of the MMR system, including the correction of …

Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC)
showing high level microsatellite instability (MSI-H). However, the distribution of BRAF …

Objective Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas),
which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC) …

Hereditary non-polyposis colon cancer (HNPCC), the most common form of hereditary colon
cancer, is a syndrome of deficient DNA mismatch repair (MMR). Five, possibly six, human …

This review gives a comprehensive overview of cancer development and links it to the
current understanding of tumorigenesis and malignant progression in colorectal cancer. The …

Serrated polyps of the large intestine, including traditional hyperplastic polyps, traditional
serrated adenomas, and more recently described sessile serrated adenomas, have gained …