[HTML][HTML] Structural biology of complement receptors

J Santos-López, K De la Paz, FJ Fernández… - Frontiers in …, 2023 - frontiersin.org
The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …

Current understanding of complement proteins as therapeutic targets for the treatment of immunoglobulin a nephropathy

A Rajasekaran, TJ Green, MB Renfrow, BA Julian… - Drugs, 2023 - Springer
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide and a frequent cause of kidney failure. Currently, the diagnosis necessitates a …

[HTML][HTML] Geographic atrophy in age-related macular degeneration: a tale of two stages

TDL Keenan - Ophthalmology Science, 2023 - Elsevier
Purpose To examine disease progression in age-related macular degeneration (AMD) at 2
distinct stages, progression to geographic atrophy (GA) versus GA expansion, by …

Absent in melanoma 2 mediates aging‐related cognitive dysfunction by acting on complement‐dependent microglial phagocytosis

L Ye, S Shu, J Jia, M Sun, S Xu, X Bao, H Bian… - Aging …, 2023 - Wiley Online Library
Pattern separation (PS) dysfunction is a type of cognitive impairment that presents early
during the aging process, and this deficit has been attributed to structural and functional …

The complement alternative pathway in health and disease—activation or amplification?

RA Harrison, CL Harris, JM Thurman - Immunological Reviews, 2023 - Wiley Online Library
In late 2020, one of us (RAH) was approached by the late Professor Sir Peter Lachmann and
invited to join him in co-editing a collection of articles focused on the alternative pathway …

Inflammatory reaction and immune response of half-smooth tongue sole (Cynoglossus semilaevis) after infection with Vibrio anguillarum

W Wang, Q Xu, S Zang, X Liu, H Liu, Z Li, Q Fan… - Fish & Shellfish …, 2023 - Elsevier
Frequently occurred bacterial diseases have seriously affected the aquaculture industry of
half-smooth tongue sole (Cynoglossus semilaevis). Notably, vibriosis, with Vibrio …

An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype

Y Zhang, Y Song, X Wang, M Shi, Y Lin, D Tao… - Cancer Immunology …, 2024 - AACR
Extensive infiltration by tumor-associated macrophages (TAM) in combination with myeloid-
derived suppressor cells constitute the immunosuppressive microenvironment and promote …

Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection

SA Tsiftsoglou, E Gavriilaki, T Touloumenidou… - Immunobiology, 2023 - Elsevier
We have attempted to explore further the involvement of complement components in the
host COVID-19 (Coronavirus disease-19) immune responses by targeted genotyping of …

[HTML][HTML] C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

L Nissinen, P Riihilä, K Viiklepp, V Rajagopal… - Scientific Reports, 2024 - nature.com
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer.
The incidence of cSCC is increasing globally and the prognosis of metastatic disease is …

Comprehensive Urinary Proteome Profiling Analysis Identifies Diagnosis and Relapse Surveillance Biomarkers for Bladder Cancer

Q Chang, Y Chen, J Yin, T Wang, Y Dai… - Journal of Proteome …, 2024 - ACS Publications
Bladder cancer (BCa) is the predominant malignancy of the urinary system. Herein, a
comprehensive urine proteomic feature was initially established for the noninvasive …