Endogenous retroviruses as modulators of innate immunity
E Russ, S Iordanskiy - Pathogens, 2023 - mdpi.com
Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …
HERVs and cancer—A comprehensive review of the relationship of human endogenous retroviruses and human cancers
E Stricker, EC Peckham-Gregory, ME Scheurer - Biomedicines, 2023 - mdpi.com
Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …
in affected cells such as sustained proliferative signaling, evasion of growth suppression …
[HTML][HTML] Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders
J Gruchot, F Herrero, U Weber-Stadlbauer… - Brain, Behavior, and …, 2023 - Elsevier
Human endogenous retroviruses (ERVs) are ancestorial retroviral elements that were
integrated into our genome through germline infections and insertions during evolution …
integrated into our genome through germline infections and insertions during evolution …
Human endogenous retroviruses role in cancer cell stemness
C Matteucci, E Balestrieri, A Argaw-Denboba… - Seminars in cancer …, 2018 - Elsevier
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …
critical issues of oncological diseases. In this scenario, increasing scientific evidences …
Natural product-derived compounds in HIV suppression, remission, and eradication strategies
While combination antiretroviral therapy (cART) has successfully converted HIV to a chronic
but manageable infection in many parts of the world, HIV continues to persist within latent …
but manageable infection in many parts of the world, HIV continues to persist within latent …
[HTML][HTML] Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection
Human endogenous retroviruses (HERVs), the remains of retroviruses infection in our
ancestors' germline cell over millions of years, take up about 8% of the human genome in …
ancestors' germline cell over millions of years, take up about 8% of the human genome in …
HUSH, a link between intrinsic immunity and HIV latency
G Chougui, F Margottin-Goguet - Frontiers in microbiology, 2019 - frontiersin.org
A prominent obstacle to HIV eradication in seropositive individuals is the viral persistence in
latent reservoir cells, which constitute an HIV sanctuary out of reach of highly active …
latent reservoir cells, which constitute an HIV sanctuary out of reach of highly active …
Endogenous retroviruses activity as a molecular signature of neurodevelopmental disorders
Human endogenous retroviruses (HERVs) are genetic elements resulting from relics of
ancestral infection of germline cells, now recognized as cofactors in the etiology of several …
ancestral infection of germline cells, now recognized as cofactors in the etiology of several …
Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces …
E Di Giorgio, L Ranzino, V Tolotto, E Dalla… - Cell Death & …, 2024 - nature.com
An important epigenetic switch marks the onset and maintenance of senescence. This
allows transcription of the genetic programs that arrest the cell cycle and alter the …
allows transcription of the genetic programs that arrest the cell cycle and alter the …
Infection by diverse HIV-1 subtypes leads to different elevations in HERV-K transcriptional levels in human T cell lines
X Li, Y Guo, H Li, X Huang, Z Pei, X Wang… - Frontiers in …, 2021 - frontiersin.org
Human endogenous retroviruses (HERVs) make up~ 8% of the human genome, and for
millions of years, they have been subject to strict biological regulation. Many HERVs do not …
millions of years, they have been subject to strict biological regulation. Many HERVs do not …