Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …

We now appreciate that the mechanism of resolution depends on an active and time-
dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called …

BACKGROUND: Human immunodeficiency virus (HIV) associated neurocognitive disorders
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …

Background High antiretroviral therapy (ART) coverage and viral suppression among
people with HIV (PWH) in Australia provide a unique context to study individual cognitive …

HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that
affect approximately half of people living with HIV (PLWH) despite effective antiretroviral …

Glia (including astrocytes, microglia, and oligodendrocytes), which constitute the majority of
cells in the brain, have many of the same receptors as neurons, secrete neurotransmitters …

Microglia are involved in many dynamic processes in the central nervous system (CNS)
including the development of inflammatory processes and neuromodulation. Several …

The HIV co-receptors, CCR5 and CXCR4, are necessary for HIV entry into target cells,
interacting with the HIV envelope protein, gp120, to initiate several signaling cascades …

Microglia are the predominant resident central nervous system (CNS) cell type productively
infected by HIV-1, and play a key role in the progression of HIV-associated dementia (HAD) …

The term opioid refers to a broad class of medications that are used most frequently for their
analgesic effects. Along with this effect, they also produce euphoria, and it is for this reason …