Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However,
the functional impact of this modification at enhancers is poorly understood. Here, we use a …

Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade,
but its treatment benefits are limited by acquired resistance, a process that remains …

Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …