Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis
pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In …

Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …

Ascofuranone (AF) and ascochlorin (AC) are meroterpenoids produced by various
filamentous fungi, including Acremonium egyptiacum (synonym: Acremonium …

Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial
enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is …

Covering: up to July 2020 Fungal meroterpenoid cyclases are a recently discovered
emerging family of membrane-integrated, non-canonical terpene cyclases. They catalyze …

Human dihydroorotate dehydrogenase (h DHODH) is an attractive tumor target essential to
de novo pyrimidine biosynthesis. Novel potent h DHODH inhibitors with low toxicity are …

Membrane proteins can be classified into two main categories—integral and peripheral
membrane proteins—depending on the nature of their membrane interaction. Peripheral …

The use of cell cycle inhibitors has necessitated a better understanding of the cell cycle in
tumor biology to optimize the therapeutic approach. Cell cycle aberrations are common in …

Many fungal metabolites show promising anticancer properties both in vitro and in animal
models, and some synthetic analogs of those metabolites have progressed into clinical …

As a key enzyme in de novo pyrimidine biosynthesis, the expression level of dihydroorotate
dehydrogenase (DHODH) has been reported to be elevated in various types of malignant …