Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical Reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Nanostructured phthalocyanine assemblies with efficient synergistic effect of type I photoreaction and photothermal action to overcome tumor hypoxia in photodynamic …

YY Zhao, L Zhang, Z Chen, BY Zheng… - Journal of the …, 2021 - ACS Publications
Most photodynamic therapy (PDT) paradigms work through the highly O2-dependent type II
photoreaction to generate singlet oxygen (1O2). The hypoxic microenvironment of solid …

Phthalocyanines as medicinal photosensitizers: Developments in the last five years

X Li, BD Zheng, XH Peng, SZ Li, JW Ying… - Coordination Chemistry …, 2019 - Elsevier
Owing to their high extinction coefficients, long absorption wavelengths, and modification
tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been …

Nanotherapeutic intervention in photodynamic therapy for cancer

AM Itoo, M Paul, SG Padaga, B Ghosh, S Biswas - ACS omega, 2022 - ACS Publications
The clinical need for photodynamic therapy (PDT) has been growing for several decades.
Notably, PDT is often used in oncology to treat a variety of tumors since it is a low-risk …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

[HTML][HTML] Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)

NEM Kaufman, S Dhingra, SD Jois, MGH Vicente - Molecules, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …

Synthesis and anticancer mechanisms of zinc (II)-8-hydroxyquinoline complexes with 1, 10-phenanthroline ancillary ligands

LQ Du, TY Zhang, XM Huang, Y Xu, MX Tan… - Dalton …, 2023 - pubs.rsc.org
Twenty new zinc (II) complexes with 8-hydroxyquinoline (H-Q1–H-Q6) in the presence of 1,
10-phenanthroline derivatives (D1–D10) were synthesized and formulated as [Zn (Q1) 2 …

[HTML][HTML] EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

Complexes of Zn (II) with a mixed tryptanthrin derivative and curcumin chelating ligands as new promising anticancer agents

ZF Wang, QX Nong, HL Yu, QP Qin, FH Pan… - Dalton …, 2022 - pubs.rsc.org
In this study, two novel curcumin (H-Cur)–tryptanthrin metal compounds—[Zn (TA) Cl2], ie,
Zn (TA), and [Zn (TA)(Cur)] Cl, ie, Zn (TAC)—were synthesized and investigated using 5-(bis …