靶标性酞菁类光敏剂的光动力疗法研究进展

李明乐, 彭孝军 - 化学学报, 2016 - sioc-journal.cn
摘要光动力治疗(Photodynamic therapy, PDT) 作为一种有别于传统癌症治疗方式的新型疗法,
近些年来受到了科学家们越来越多的关注. 它凭借着自身创伤性小, 毒性低微, 适用性好 …

[PDF][PDF] 光动力治疗中提高光敏剂靶向性的研究进展

杨宇鑫, 赵学泽, 樊江莉, 彭孝军 - 化工学报, 2021 - hgxb.cip.com.cn
由于具有微创, 时空选择性高, 重复应用不产生耐药性等优点, 光动力治疗被认为是一种极具前景
的新型癌症治疗方法. 但是, 传统的光敏剂靶向性有限, 会对正常组织产生毒副作用 …

Development of targeted photodynamic therapy drugs by combining a zinc phthalocyanine sensitizer with TSPO or EGFR binding groups: the impact of the number of …

I Toubia, C Nguyen, S Diring, M Onofre… - Organic & …, 2023 - pubs.rsc.org
Drug-targeted delivery has become a top priority in the world of medicine in order to develop
more efficient therapeutic agents. This is important as a critical underlying problem in cancer …

Thermosensitive nanocomposite gel loaded zinc phthalocyanine for photodynamic therapy

M Yang, X Lu, L Tang, Y Fu, P Yang - Journal of Polymer Research, 2020 - Springer
The purpose of this work was first to propose a thermosensitive hydrogel incorporating Zn
phthalocyanine loaded mixed micelles for drug delivery. The mixed micelles was prepared …

Synthesis, Spectroscopic and Fibroblast Activation Protein (FAP)‐Responsive Properties of Phthalocyanine‐Doxorubicin Conjugates

XH Peng, SF Chen, CH Xu, BY Zheng, MR Ke… - …, 2018 - Wiley Online Library
A series of novel phthalocyanine‐doxorubicin (Pc‐DOX) conjugates have been prepared
with a fibroblast activation protein (FAP)‐sensitive linker of glycine‐proline (Gly‐Pro) …

Synthesis and evaluation of a novel 68Ga-NODAGA-Erlotinib analogue towards PET imaging of Epidermal Growth Factor Receptor over-expressing cancers

A Jain, M Kameswaran, U Pandey… - Chemical Biology …, 2018 - pubs.iscience.in
In this paper we report the synthesis of 68Ga labeled NODAGA-Erlotinib for imaging of
EGFR over-expressing tumors. NODAGA-Erlotinib conjugate was synthesized by reaction of …

Quinolin-8-yloxy-substituted zinc(II) phthalocyanines for enhanced in vitro photodynamic therapy

J Chen, Y Fang, H Liu, N Chen, S Chen… - Journal of Porphyrins …, 2018 - World Scientific
Photodynamic therapy (PDT) is an innovative and promising modality to treat various
tumors. In this study, two novel zinc (II) phthalocyanines substituted with quinolin-8-yloxy …

[PDF][PDF] EGFR-Targeted Photodynamic Ther-apy. Pharmaceutics 2022, 14, 241

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - 2022 - researchgate.net
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

Enhanced Efficacy of Gefitinib in Drug‐sensitive and Drug‐resistant Cancer Cell Lines after Arming with a Singlet Oxygen Releasing Moiety

K Huang, B Huo, D Li, J Xue, J Chen - ChemMedChem, 2020 - Wiley Online Library
Attractive results have been achieved with small‐molecule target‐based drugs in the
anticancer field; however, enhancing their treatment effect and solving the problem of drug …

[HTML][HTML] Synthesis and characterization of tetrakis (allyloxy) substituted Zn (II), Pt (II) and Pd (II) phthalocyaninates

ID Burtsev, AN Volov, LG Tomilova - Макрогетероциклы, 2020 - cyberleninka.ru
2 (3)-Tetrakis (allyloxy) substituted phthalocyanine complexes of Zn (II), Pt (II) and Pd (II)
have been obtained from a phthalocyanine ligand in high yields (up to 90%). Both thermal …