Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

In recent years, proteolysis-targeting chimeras (PROTACs), capable of achieving targeted
protein degradation, have proven their great therapeutic potential and usefulness as …

Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …

We investigate the use of confidence scores to evaluate the accuracy of a given AlphaFold
(AF2) protein model for drug discovery. Prediction of accuracy is improved by not …

Intrinsically disordered domains represent attractive therapeutic targets because they play
key roles in cancer, as well as in neurodegenerative and infectious diseases. They are …

Abstract The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot. org)
is the major repository of manually curated annotations of intrinsically disordered proteins …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Intrinsic disorder prediction is an active area that has developed over 100 predictors. We
identify and investigate a recent trend towards the development of deep neural network …

Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …