Prostate cancer is the second most common malignancy in men worldwide. Prostate cancer
can be treated by surgery, radiotherapy and hormone therapy. The latter, in the form of …

Pyroptosis is a form of programmed cell death associated with activation of inflammasomes
and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the …

The physiological functions of endothelial cells control vascular tone, permeability,
inflammation, and angiogenesis, which significantly help to maintain a healthy vascular …

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to
endogenous hazard signals and metabolites in the circulatory system. The senescence and …

Accumulating evidence strongly support the key role of NLRP3-mediated pyroptosis in the
pathogenesis and progression of vascular endothelial dysfunction associated with diabetes …

The review considers modern data on the mechanisms of activation and redox regulation of
the NLRP3 inflammasome and gasdermins, as well as the role of selenium in these …

Diabetic vascular complications are prevalent and severe among diabetic patients,
profoundly affecting both their quality of life and long-term prospects. These complications …

Inflammatory diseases compromise a clinically common and diverse group of conditions,
causing detrimental effects on body functions. Gasdermins (GSDM) are pore-forming …

The vascular endothelium dynamically responds to environmental cues and plays a pivotal
role in maintaining vascular homeostasis by regulating vasomotor tone, blood cell trafficking …

Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are
severe respiratory conditions with complex pathogenesis, in which endothelial cells (ECs) …