Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and
cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With …

Cardiovascular development is initiated soon after gastrulation as bilateral precardiac
mesoderm is progressively symmetrically determined at both sides of the developing …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of heart physiology
and disease, although the studies unveiling their modes of action are still limited to few …

An effective loss-of-function study is necessary to investigate the biological function of long
non-coding RNA (lncRNA). Various approaches are available, including RNA silencing …

Congenital heart disease is the most common birth defect worldwide. Defective cardiac
myogenesis is either a major presentation or associated with many types of congenital heart …

Myocardial cell fate specification takes place during the early stages of heart development
as the precardiac mesoderm is configured into two symmetrical sets of bilateral precursor …

Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of
death worldwide. One of the long-standing goals of scientists is to repair heart tissue …

Background Long noncoding RNAs (lncRNAs) have been shown to be involved in the
regulation of numerous biological processes in embryonic development. We aimed to …

The objective of this study was to understand and measure epigenetic changes associated
with the occurrence of CHDs by utilizing the discordant monozygotic twin model. A unique …

Congenital heart disease (CHD) is a serious condition with unknown etiology. In a recent
study, a compound heterozygous mutation (c. 3526C> T [p. Arg1176Trp] and c. 4643A> G [p …