Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy
MJ Ramaiah, AD Tangutur, RR Manyam - Life sciences, 2021 - Elsevier
The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …
Epigenetic protein families: a new frontier for drug discovery
Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …
establishes normal cellular phenotypes but also contributes to human diseases. At the …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
[HTML][HTML] Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
M Göttlicher, S Minucci, P Zhu, OH Krämer… - The EMBO …, 2001 - embopress.org
Histone deacetylases (HDACs) play important roles in transcriptional regulation and
pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation …
pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation …
[HTML][HTML] Negative control of p53 by Sir2α promotes cell survival under stress
The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene
silencing as well as aging in yeast. Here, we show that mammalian Sir2α physically interacts …
silencing as well as aging in yeast. Here, we show that mammalian Sir2α physically interacts …
Histone deacetylase inhibitors: molecular mechanisms of action
WS Xu, RB Parmigiani, PA Marks - Oncogene, 2007 - nature.com
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
Histone deacetylases and cancer: causes and therapies
PA Marks, RA Rifkind, VM Richon, R Breslow… - Nature Reviews …, 2001 - nature.com
Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …
acetylation status of histones. This acetylation affects the regulation of gene expression, and …
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
RW Johnstone - Nature reviews Drug discovery, 2002 - nature.com
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
PA Marks, R Breslow - Nature biotechnology, 2007 - nature.com
In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and
terminal differentiation of transformed cells, we followed a path that led us to discover …
terminal differentiation of transformed cells, we followed a path that led us to discover …
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Insufficient T cell infiltration into noninflamed tumors, such as hepatocellular carcinoma
(HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of …
(HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of …