Base excision repair mechanisms have been analyzed in nuclear and mitochondrial DNA.
We measured the size and position of the newly incorporated DNA repair patch in various …

Yerba mate (Ilex paraguariensis) is rich in several bioactive compounds that can act as free
radical scavengers. Since oxidative DNA damage is involved in various pathological states …

Recent studies show an increase in DNA oxidation in brain and cerebrospinal fluid (CSF),
and decreased levels of the free repair product in CSF in Alzheimer's disease (AD). This is a …

Zearalenone (ZEA), one of the mycotoxins, exerts different mechanisms of toxicity in different
cell types at different doses. It can not only stimulate cell proliferation but also inhibit cell …

Ferric nitrilotriacetate (Fe-NTA) causes renal proximal tubular necrosis, a consequence of
iron ion-mediated free-radicalassociated damage, that finally leads to a high incidence of …

We recently showed that abasic sites, uracil mismatches, nicks, and gaps can trap DNA
topoisomerase I (top1) when these lesions are introduced in the vicinity of a top1 cleavage …

Bleomycin, a radiomimetic drug currently used in human cancer therapy, is a well known
carcinogen. Its toxicity is mostly attributed to its potentiality to induce DNA double strand …

Oxidative stress in microbial cells shares many similarities with other cell types but it has its
specific features which may differe in prokaryotic and eukaryotic cells. We survey here the …

This review article presents, an overview of the DNA glycosylases that recognize oxidized
DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can …

Oxoguanine-DNA glycosylase-1 (OGG1) is the primary enzyme for repairing 7, 8-dihydro-8-
oxoguanine (8-oxoG) via the DNA base excision repair pathway (OGG1-BER). Accumulation …