Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response

JR Polimeni, LD Lewis - Progress in neurobiology, 2021 - Elsevier
Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …

Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics

AA Linninger, K Tangen, CY Hsu… - Annual Review of Fluid …, 2016 - annualreviews.org
Cerebrospinal fluid (CSF) is not stagnant but displays fascinating oscillatory flow patterns
inside the ventricular system and reversing fluid exchange between the cranial vault and …

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

IG Gould, P Tsai, D Kleinfeld… - Journal of Cerebral …, 2017 - journals.sagepub.com
The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …

[PDF][PDF] Brain microvasculature has a common topology with local differences in geometry that match metabolic load

X Ji, T Ferreira, B Friedman, R Liu, H Liechty, E Bas… - Neuron, 2021 - cell.com
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …

Mapping oxygen concentration in the awake mouse brain

DG Lyons, A Parpaleix, M Roche, S Charpak - Elife, 2016 - elifesciences.org
Although critical for brain function, the physiological values of cerebral oxygen concentration
have remained elusive because high-resolution measurements have only been performed …

Multiscale modelling of blood flow in cerebral microcirculation: Details at capillary scale control accuracy at the level of the cortex

M Peyrounette, Y Davit, M Quintard, S Lorthois - PloS one, 2018 - journals.plos.org
Aging or cerebral diseases may induce architectural modifications in human brain
microvascular networks, such as capillary rarefaction. Such modifications limit blood and …

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction

B Li, TV Esipova, I Sencan, K Kılıç, B Fu, M Desjardins… - Elife, 2019 - elifesciences.org
Our understanding of how capillary blood flow and oxygen distribute across cortical layers to
meet the local metabolic demand is incomplete. We addressed this question by using two …

[HTML][HTML] Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks

P Balogh, P Bagchi - Physics of Fluids, 2018 - pubs.aip.org
Partitioning of red blood cells (RBCs) at vascular bifurcations has been studied over many
decades using in vivo, in vitro, and theoretical models. These studies have shown that RBCs …

Methods to label, image, and analyze the complex structural architectures of microvascular networks

BA Corliss, C Mathews, R Doty, G Rohde… - …, 2019 - Wiley Online Library
Microvascular networks play key roles in oxygen transport and nutrient delivery to meet the
varied and dynamic metabolic needs of different tissues throughout the body, and their …

Adaptive constrained constructive optimisation for complex vascularisation processes

GDM Talou, S Safaei, PJ Hunter, PJ Blanco - Scientific Reports, 2021 - nature.com
Mimicking angiogenetic processes in vascular territories acquires importance in the analysis
of the multi-scale circulatory cascade and the coupling between blood flow and cell function …