Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …

Introduction Altered epigenetic map is frequently observed in cancer and recent
investigations have demonstrated a pertinent role of epigenetic modifications in the …

The active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxycamptothecin (SN38), is
100–1000 times more active than CPT-11 and has shown inhibitory effects on a range of …

Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against
various cancers. However, its clinical application is severely limited by poor water solubility …

Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …

DNA topoisomerases are important enzymes that stabilize DNA supercoiling and resolve
entanglements. There are two main types of topoisomerases in all cells: type I, which causes …

For the first time, two new mononuclear platinum (II) coordination compounds,[Pt
(L1)(DMSO) Cl](PtL1) and [Pt (L2)(DMSO) Cl](PtL2) with the 5-(ethoxymethyl)-8 …

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global
morbidity, disability, and mortality, highlighting the necessity for transformative treatment …

Combinatorial inhibition of Topoisomerase 1 (TOP1) and Poly (ADP-ribose) polymerase 1
(PARP1) is an attractive therapeutic strategy which is under active investigation to address …

Cancer is a leading cause of death globally, with limited treatment options and several
limitations. Chemotherapeutic agents often result in toxicity which long-term conventional …