Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for
sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone …

Disorders of body composition, including obesity and osteoporosis, have reached record
proportions. Coincidentally, our understanding of the mechanisms controlling body mass …

The effect of metabolic stress on the bone marrow microenvironment is poorly defined. We
show that high-fat diet (HFD) decreased long-term Lin− Sca-1+ c-Kit+(LSK) stem cells and …

A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

Bone can adapt its structure in response to mechanical stimuli. At the cellular level, this
involves changes in chromatin organization, gene expression, and differentiation, but the …

Physical inactivity has been recognized, by the World Health Organization as the fourth
cause of death (5.5% worldwide). On the contrary, physical activity (PA) has been …