Advances in human oxytocin measurement: challenges and proposed solutions

BA Tabak, G Leng, A Szeto, KJ Parker… - Molecular …, 2023 - nature.com
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes,
may hold promise as a therapeutic agent in treating social impairments in patient …

The paraventricular nucleus of the thalamus as an integrating and relay node in the brain anxiety network

GJ Kirouac - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
The brain anxiety network is composed of a number of interconnected cortical regions that
detect threats and execute appropriate defensive responses via projections to the shell of …

The neuroscience of social feelings: mechanisms of adaptive social functioning

PJ Eslinger, S Anders, T Ballarini, S Boutros… - Neuroscience & …, 2021 - Elsevier
Social feelings have conceptual and empirical connections with affect and emotion. In this
review, we discuss how they relate to cognition, emotion, behavior and well-being. We …

Neural circuits of social behaviors: Innate yet flexible

D Wei, V Talwar, D Lin - Neuron, 2021 - cell.com
Social behaviors, such as mating, fighting, and parenting, are fundamental for survival of any
vertebrate species. All members of a species express social behaviors in a stereotypical and …

Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse

KY Choe, RAI Bethlehem, M Safrin, H Dong, E Salman… - Neuron, 2022 - cell.com
The neural basis of abnormal social behavior in autism spectrum disorders (ASDs) remains
incompletely understood. Here we used two complementary but independent brain-wide …

Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance

N Duque-Wilckens, LY Torres… - Proceedings of the …, 2020 - National Acad Sciences
Oxytocin increases the salience of both positive and negative social contexts and it is
thought that these diverse actions on behavior are mediated in part through circuit-specific …

Neural functions of hypothalamic oxytocin and its regulation

P Wang, SC Wang, X Liu, S Jia, X Wang, T Li… - ASN …, 2022 - journals.sagepub.com
Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT
over past decades, our understanding of its neural functions and their regulation remains …

Wireless optogenetic stimulation of oxytocin neurons in a semi-natural setup dynamically elevates both pro-social and agonistic behaviors

S Anpilov, Y Shemesh, N Eren, H Harony-Nicolas… - Neuron, 2020 - cell.com
Complex behavioral phenotyping techniques are becoming more prevalent in the field of
behavioral neuroscience, and thus methods for manipulating neuronal activity must be …

Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens

AV Williams, N Duque-Wilckens… - …, 2020 - nature.com
Oxytocin is currently being considered as a novel therapeutic for anxiety disorders due to its
ability to promote affiliative behaviors. In the nucleus accumbens (NAc) activation of oxytocin …

Role of oxytocin in the control of stress and food intake

T Onaka, Y Takayanagi - Journal of neuroendocrinology, 2019 - Wiley Online Library
Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake.
The oxytocin receptor is located in various brain regions, including the sensory information …