The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

As one of the fundamental components of Astragalus membranaceus, astragaloside IV (AST
IV) exerts protective effects against cerebral ischemia‐reperfusion injury (CIRI) …

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

The poor drug delivery to cerebral ischemic regions is a key challenge of ischemic stroke
treatment. Inspired by the intriguing blood–brain barrier (BBB)-penetrating ability of 4T1 …

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P …

Acute hypoxia increases the formation of reactive oxygen species (ROS) in the brain.
However, the effect of reoxygenation, unavoidable to achieve full recovery of the hypoxic …

Background Results of initial randomised trials of endovascular treatment for ischaemic
stroke, published in 2013, were neutral but limited by the selection criteria used, early …

Globally, stroke is a leading cause of death and long-term disability. Over the past decades,
several efforts have attempted to discover new drugs or repurpose existing therapeutics to …

The modification of methyltransferase-like (METTL) enzymes plays important roles in various
cellular responses by regulating microRNA expression. However, how m6A modification is …