Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Background The investigation of treatment mechanisms in randomized controlled trials has
considerable clinical and theoretical relevance. Despite the empirical support for the effect of …

We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

Background: Recent insights into the role of the human microbiota in cognitive and affective
functioning have led to the hypothesis that probiotic supplementation may act as an adjuvant …

Background Individuals with a history of recurrent depression have a high risk of repeated
depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the …

The relationship between mindfulness and self-compassion is explored in the health care
literature, with a corollary emphasis on reducing stress in health care workers and providing …

Mindfulness-based interventions (MBIs) are at a pivotal point in their future development.
Spurred on by an ever-increasing number of studies and breadth of clinical application, the …

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or
extrinsic stimuli by reorganizing its structure, function and connections. Major advances in …

For the past hundred years, mechanisms of change have been the black box of
psychotherapy. Thousands of studies failed to produce consistent findings, even concerning …

Mindfulness-based cognitive therapy (MBCT) is an efficacious psychosocial intervention for
recurrent depression (Kuyken et al., 2008; Ma & Teasdale, 2004; Teasdale et al., 2000). To …