[HTML][HTML] An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

[HTML][HTML] Isorhamnetin: A review of pharmacological effects

G Gong, YY Guan, ZL Zhang, K Rahman… - Biomedicine & …, 2020 - Elsevier
Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae
rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive …

[HTML][HTML] Nrf2 signaling pathway: Pivotal roles in inflammation

SMU Ahmed, L Luo, A Namani, XJ Wang… - Biochimica et Biophysica …, 2017 - Elsevier
Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …

Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of …

H Zhu, Q Jin, Y Li, Q Ma, J Wang, D Li, H Zhou… - Cell Stress and …, 2018 - Springer
The cardiac microvascular reperfusion injury is characterized by the microvascular
endothelial cells (CMECs) oxidative damage which is responsible for the progression of …

[HTML][HTML] Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing …

SY Kim, CY Jin, CH Kim, YH Yoo… - International …, 2019 - spandidos-publications.com
Isorhamnetin, which is a flavonoid predominantly found in fruits and leaves of various plants,
including Hippophae rhamnoides L. and Oenanthe javanica (Blume) DC, is known to …

Network Pharmacology‐Based and Molecular Docking‐Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder

Y Liu, L Yu, J Zhang, D Xie, X Zhang… - BioMed research …, 2021 - Wiley Online Library
This study is aimed at exploring the possible mechanism of action of the Suanzaoren
decoction (SZRD) in the treatment of Parkinson's disease with sleep disorder (PDSD) based …

[HTML][HTML] Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Centella asiatica

A Hambali, J Kumar, NFM Hashim, S Maniam… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterised by the
presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau …

Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: role of antioxidant defense, cholinergic and …

IO Ishola, MO Osele, MC Chijioke, OO Adeyemi - Brain research, 2019 - Elsevier
Abstract Isorhamnetin (IRN), a 3′-O-methylated metabolite of quercetin has antioxidant,
anti-inflammatory and neuroprotective properties. In this study, we investigated the learning …

[HTML][HTML] Itaconate suppresses formation of neutrophil extracellular traps (NETs): involvement of hypoxia-inducible factor 1α (Hif-1α) and heme oxygenase (HO-1)

G Burczyk, I Cichon, E Kolaczkowska - Frontiers in immunology, 2022 - frontiersin.org
Neutrophil extracellular traps (NETs) immobilize pathogens during early stages of systemic
inflammation but as the reaction progresses they become detrimental to endothelial cells …

[HTML][HTML] Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice

X Lu, T Liu, K Chen, Y Xia, W Dai, S Xu, L Xu… - Biomedicine & …, 2018 - Elsevier
Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn
(Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti …