Simple Summary The IL-12 family cytokines play an important role in regulating the tumor
immune contexture. Recent efforts geared towards the development of better immune …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …

CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by
regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can …

In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000
people died. Moreover, men are 4 times more likely than women to be diagnosed with BC …

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …

Abstract IL-17A-producing CD4+ T helper cells (Th17) are crucial for the development of
inflammatory and autoimmune diseases and thus are exploited for clinical immunotherapies …

Periodontopathic bacteria constantly stimulate the host, which causes an immune response,
leading to host‐induced periodontal tissue damage. The complex interaction and imbalance …

The importance of IL‐23 and its specific receptor, IL‐23R, in the pathogenesis of several
chronic inflammatory diseases has been established, but the underlying pathological …

Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the
pathogenesis of ocular immune disease. The association between pathogenic Th17 cells …

Summary Inappropriate CD4+ T helper (Th) differentiation can compromise host immunity or
promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we …