[HTML][HTML] SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
[HTML][HTML] Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia
HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
[HTML][HTML] Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
A García-García, R Pérez de Diego, C Flores… - Journal of Experimental …, 2023 - rupress.org
Disclosures: C. Flores reported grants from Instituto de Salud Carlos III, Spanish Ministry of
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J …
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J …
[HTML][HTML] COVID-19 annual update: a narrative review
M Biancolella, VL Colona, L Luzzatto, JL Watt… - Human genomics, 2023 - Springer
Three and a half years after the pandemic outbreak, now that WHO has formally declared
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …
[HTML][HTML] Understanding COVID-19 in children: immune determinants and post-infection conditions
Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …
adults. On the other hand, the presence of a wide range of inflammatory manifestations …
[HTML][HTML] Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19
RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
[HTML][HTML] Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
P Bastard, A Gervais, M Taniguchi, L Saare… - Journal of Experimental …, 2024 - rupress.org
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …
[HTML][HTML] Human inherited complete STAT2 deficiency underlies inflammatory viral diseases
Type I IFNs, a family of cytokines that signal through a single receptor and signaling
mechanism, were originally named for their ability to interfere with viral replication. While …
mechanism, were originally named for their ability to interfere with viral replication. While …
Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses
M Moniruzzaman, MP Erazo Garcia… - FEMS microbiology …, 2023 - academic.oup.com
The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …
“giant viruses” have a long evolutionary history that dates back to the early diversification of …
[HTML][HTML] Long COVID: what is known and what gaps need to be addressed
Introduction Long COVID is a chronic condition that follows after acute COVID-19 and is
characterized by a wide range of persistent, cyclic symptoms. Sources of data PubMed …
characterized by a wide range of persistent, cyclic symptoms. Sources of data PubMed …