RNA has diverse cellular functionality, including regulating gene expression, protein
translation, and cellular response to stimuli, due to its intricate structures. Over the past …

RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …

RNA is a major player in cellular function, and consequently can drive a number of disease
pathologies. Over the past several years, small molecule‐RNA targeting (smRNA targeting) …

We report the discovery of drug-like small molecules that bind specifically to the precursor of
the oncogenic and pro-inflammatory microRNA-21 with mid-nanomolar affinity. The small …

CD24 is overexpressed in various tumours and considered a regulator of cell migration,
invasion, and proliferation. Recent studies have found that CD24 on ovarian cancer (OC) …

Targeting proteins' enzymatic functions with small molecule inhibitors, as well as functions of
receptor proteins with small-molecule agonists and antagonists, were the major forms of …

Targeting RNA with small molecules is a major challenge of current medicinal chemistry,
and the identification and design of original scaffolds able to selectively interact with an RNA …

Small molecules targeting the ubiquitous latent ribonuclease (RNase L), which has limited
sequence specificity toward single-stranded RNA substrates, hold great potential to be …

Targeted inhibition of oncogenic microRNAs provides a promising anti-cancer approach.
Here, we report a bifunctional chimera for ligand-directed regulation of target oncogenic …

Programmable and precise regulation of genetic information is crucial in bioengineering and
biomedicine; however, it remains challenging to implement this objective. Here we deployed …