Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to
nonsteroidal anti-inflammatory drugs (NSAIDs) for treating pathological conditions governed …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Cell migration is a fundamental biological process involved in normal physiology. Altered
motile phenotypes are however often associated with the development and progression of …

Aspirin taken for several years at doses of at least 75 mg daily reduced long-term incidence
and mortality due to colorectal cancer. The finding of aspirin benefit at low-doses given once …

Myeloid-derived suppressor cells (MDSCs) are critical mediators of tumor-associated
immune suppression, with their numbers and activity strongly increased in most human …

One of the most common features of exposure of skin to ultraviolet (UV) light is the induction
of inflammation, a contributor to tumorigenesis, which is characterized by the synthesis of …