[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine
P Chen, J Zhang, C Wang, Y Chai, A Wu, N Huang… - Phytomedicine, 2022 - Elsevier
Background: Parkinson's disease (PD) is the second most common neurodegenerative
disease with no treatment currently available to modify its progression. Traditional Chinese …
disease with no treatment currently available to modify its progression. Traditional Chinese …
Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice
Dietary restriction through low-calorie intake or intermittent fasting benefits many organs,
including the brain. This study investigated the neuroprotective effects of fasting in a 1 …
including the brain. This study investigated the neuroprotective effects of fasting in a 1 …
[HTML][HTML] Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases
Neurodegenerative diseases (NDs) encompass a broad range of conditions characterized
by progressive neuronal degeneration and death and manifesting with a variety of signs and …
by progressive neuronal degeneration and death and manifesting with a variety of signs and …
[HTML][HTML] Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson's disease model mice
L Wang, S Li, Y Jiang, Z Zhao, Y Shen, J Zhang… - Journal of Functional …, 2021 - Elsevier
Probiotic has significant potential as a therapeutic target for Parkinson's disease (PD), but
how it contributes to disease processes and symptoms remains uncertain. This study aimed …
how it contributes to disease processes and symptoms remains uncertain. This study aimed …
Rhynchophylline alleviates neuroinflammation and regulates metabolic disorders in a mouse model of Parkinson's disease
C Zhang, Z Xue, L Zhu, J Zhou, L Zhuo, J Zhang… - Food & Function, 2023 - pubs.rsc.org
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder with
limited therapeutic agents. Rhynchophylline (RIN), a tetracyclic oxindole alkaloid isolated …
limited therapeutic agents. Rhynchophylline (RIN), a tetracyclic oxindole alkaloid isolated …
Transcriptome revealing the dual regulatory mechanism of ethylene on the rhynchophylline and isorhynchophylline in Uncaria rhynchophylla
X Li, X Wang, W Qiang, H Zheng, L ShangGuan… - Journal of plant …, 2022 - Springer
Rhynchophylline (RIN) and isorhynchophylline (IRN) are extracted from Uncaria
rhynchophylla, which are used to treat Alzheimer's disease. However, the massive …
rhynchophylla, which are used to treat Alzheimer's disease. However, the massive …
Cellular effects of rhynchophylline and relevance to sleep regulation
MN Ballester Roig, T Leduc, CC Areal, V Mongrain - Clocks & Sleep, 2021 - mdpi.com
Uncaria rhynchophylla is a plant highly used in the traditional Chinese and Japanese
medicines. It has numerous health benefits, which are often attributed to its alkaloid …
medicines. It has numerous health benefits, which are often attributed to its alkaloid …
[HTML][HTML] A comprehensive review of phytochemistry, pharmacology and clinical applications of Uncariae Ramulus Cum Uncis
Z Zhang, Y Li, G Wu, YM Li, D Zhang… - Arabian Journal of …, 2023 - Elsevier
Abstract Objectives Uncariae Ramulus Cum Uncis (URCU) belonging to the genus Uncaria
is widely distributed in China and used in folk medicine, which has the effect of clearing heat …
is widely distributed in China and used in folk medicine, which has the effect of clearing heat …
PI3K/Akt signaling pathway ameliorates oxidative stress-induced apoptosis upon manganese exposure in PC12 cells
Y Tan, H Cheng, C Su, P Chen, X Yang - Biological Trace Element …, 2022 - Springer
Manganese (Mn)-induced neurotoxicity has aroused public concerns for many years, but its
precise mechanism is still poorly understood. Herein, we report the impacts of the …
precise mechanism is still poorly understood. Herein, we report the impacts of the …