Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Macroautophagy decreases with age, and this change is considered a hallmark of the aging
process. It remains unknown whether mitophagy, the essential selective autophagic …

Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …

DNA variants that modulate life span provide insight into determinants of health, disease,
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Sarcopenia, the age-related loss of skeletal muscle mass and function, can dramatically
impinge on quality of life and mortality. While mitochondrial dysfunction and imbalanced …

Physical training is a potent therapeutic approach for improving mitochondrial health
through peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) …