Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as
a hepatokine. This hormone circulates to its target tissues (eg, brain, adipose tissue), which …

Abstract Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that
acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast …

Iron is an essential element for all living organisms, but produces toxic oxidants. Thus, iron
homeostasis is tightly regulated in mammals. Hepcidin-25 (hepcidin) has emerged as a …

Background Fibroblast growth factor 21 (FGF21) is an emerging metabolic regulator
associated with glucose and lipid metabolism, and it is still unclear whether FGF21 is related …

Iron is an essential trace element involved in oxidation–reduction reactions, oxygen
transport and storage, and energy metabolism. Iron in excess can be toxic for cells, since …

Hepcidin is a key regulator of iron homeostasis and plays a role in the pathogenesis of
anaemia of chronic disease. Its levels are increased in patients with chronic kidney disease …

Chronic kidney disease (CKD) is a global public health problem. Cardiovascular disease
(CVD) is a common comorbidity and a major cause of mortality in CKD population. While …