The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required
throughout embryonic and postnatal development and also regulates multiple homeostatic …

The fibroblast growth factor receptors (FGFRs) regulate important biological processes
including cell proliferation and differentiation during development and tissue repair. Over the …

Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all
characterized by common core symptoms such as impaired social skills and communication …

The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed
in eukaryotic cells and involved in a multitude of intracellular protein interactions. Grb2 plays …

Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses
that are crucial for development and wound healing. However, aberrant FGFR activity leads …

The fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for
embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular …

Invasion and intrahepatic metastasis are major factors of poor prognosis in patients with
hepatocellular carcinoma (HCC). In this study, we show that increased Src homolog and …

Ras guanine nucleotide-releasing protein 1 (RasGRP1), a Ras activator, is upregulated in
hepatocellular carcinoma (HCC) and other kinds of cancer and is associated with the poor …

Cellular signaling by fibroblast growth factor receptors (FGFRs) is a highly regulated process
mediated by specific interactions between distinct subsets of fibroblast growth factor (FGF) …

Receptor tyrosine kinase (RTK)-mediated hyperactivation of the MAPK/Erk pathway is
responsible for a large number of pathogenic outcomes including many cancers …