Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …

FcγRs have been the focus of extensive research due to their key role linking innate and
humoral immunity and their implication in both inflammatory and infectious disease. Within …

Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

Myasthenia gravis (MG) is the prototypical autoimmune disorder caused by specific
autoantibodies at the neuromuscular junction. Broad-based immunotherapies, such as …

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …

Cell-surface Fcγ receptors mediate innate and adaptive immune responses. Human Fcγ
receptor I (hFcγRI) binds IgGs with high affinity and is the only Fcγ receptor that can …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of
immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and …

ABSTRACT The neonatal Fc receptor (FcRn) promotes antibody recycling through rescue
from normal lysosomal degradation. The binding interaction is pH-dependent with high …