Background Knee osteoarthritis (OA) is a chronic progressive disease that imparts a
substantial socioeconomic burden to society and healthcare systems. The prevalence of …

Cartilage is a tension-and load-bearing tissue and has a limited capacity for intrinsic self-
healing. While microfracture and arthroplasty are the conventional methods for cartilage …

The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

There is currently widespread interest within the biomaterial field to locally deliver
biomolecules for bone and cartilage regeneration. Substantial work to date has focused on …

Cartilage injuries cause pain and loss of function, and if severe may result in osteoarthritis
(OA). 3D bioprinting is now a tangible option for the delivery of bioscaffolds capable of …

Knee osteoarthritis (KOA) is associated with a high risk of sarcopenia. Both intra-articular
injections (IAIs) and physical therapy (PT) exert benefits in KOA. This network meta-analysis …

This study proposes a magnetically actuated microscaffold with the capability of targeted
mesenchymal stem cell (MSC) delivery for articular cartilage regeneration. The …

Purpose Elucidating subchondral bone remodeling in preclinical models of traumatic
meniscus injury may address clinically relevant questions about determinants of knee …

Chronic inflammation is a common underlying factor in osteoarthritis (OA) and most age-
related degenerative diseases. As conventional therapies help only in partial alleviation of …