MicroRNAs (miRNAs) are emerging as a novel class of non-coding RNA molecules that
regulate gene expression at a post-transcriptional level. More than 1000 miRNAs have been …

Glioblastoma multiforme (GBM) is an incurable form of brain cancer with a very poor
prognosis. Because of its highly invasive nature, it is impossible to remove all tumor cells …

Background Trastuzumab resistance followed by metastasis is a major obstacle for
improving the clinical outcome of patients with advanced human epidermal growth factor …

Unicellular marine algae have promise for providing sustainable and scalable biofuel
feedstocks, although no single species has emerged as a preferred organism. Moreover …

Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients.
Despite impressive initial clinical responses, the majority of patients eventually develop …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Background Chemotherapy is an important component in the treatment paradigm for breast
cancers. However, the resistance of cancer cells to chemotherapeutic agents frequently …

MicroRNAs influence hematopoietic differentiation, but little is known about their effects on
the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

MicroRNAs regulate temporal transitions in gene expression associated with cell fate
progression and differentiation throughout animal development. Genetic analysis of …