All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …

Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic
lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Tumours comprise multiple phenotypically distinct subpopulations of cells, some of which
are proposed to possess stem cell‐like properties, being able to self‐renew, seed and …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …