MITF—the first 25 years
CR Goding, H Arnheiter - Genes & development, 2019 - genesdev.cshlp.org
All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …
Roles of mitogen-activated protein kinases in osteoclast biology
K Lee, I Seo, MH Choi, D Jeong - International journal of molecular …, 2018 - mdpi.com
Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …
communication between bone-forming osteoblasts and bone-degrading osteoclasts …
Osteoclast differentiation and activation
WJ Boyle, WS Simonet, DL Lacey - Nature, 2003 - nature.com
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic
lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that …
lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that …
Melanoma: from mutations to medicine
H Tsao, L Chin, LA Garraway… - Genes & …, 2012 - genesdev.cshlp.org
Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …
MITF in melanoma: mechanisms behind its expression and activity
ML Hartman, M Czyz - Cellular and Molecular Life Sciences, 2015 - Springer
MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …
MITF: master regulator of melanocyte development and melanoma oncogene
C Levy, M Khaled, DE Fisher - Trends in molecular medicine, 2006 - cell.com
Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …
melanocyte development, function and survival by modulating various differentiation and …
Melanocytes and the Microphthalmia Transcription Factor Network
E Steingrímsson, NG Copeland, NA Jenkins - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …
Cancer stem cells versus phenotype‐switching in melanoma
KS Hoek, CR Goding - Pigment cell & melanoma research, 2010 - Wiley Online Library
Tumours comprise multiple phenotypically distinct subpopulations of cells, some of which
are proposed to possess stem cell‐like properties, being able to self‐renew, seed and …
are proposed to possess stem cell‐like properties, being able to self‐renew, seed and …
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
S Theoleyre, Y Wittrant, SK Tat, Y Fortun… - Cytokine & growth factor …, 2004 - Elsevier
The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …
biology over this period of time has been marked by a number of key discoveries that have …
Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy
C Wellbrock, I Arozarena - Pigment cell & melanoma research, 2015 - Wiley Online Library
Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …