Upon viral infection, the major defense mounted by the host immune system is activation of
the interferon (IFN)-mediated antiviral pathway. In order to complete their life cycles, viruses …

Host cells respond to viral infections by synthesizing and producing antiviral molecules such
as type I interferons (IFN). The Kaposi sarcoma-associated herpesvirus (KSHV) encodes …

The type I interferon (IFN) response is a principal component of our immune system that
allows to counter a viral attack immediately upon viral entry into host cells. Upon …

Early detection of infectious nucleic acids released from invading pathogens by the innate
immune system is critical for immune defense. Detection of these nucleic acids by host …

Type I interferons (IFN-α/β) were originally discovered by their strong and direct antiviral
activity [A. Isaacs, J. Lindenmann, Virus interference. I. The interferon, Proc. R. Soc. Lond. B …

The most recently identified human herpesvirus is Kaposi's sarcoma-associated herpesvirus
(KSHV). It causes Kaposi's sarcoma, a tumour occurring most commonly in untreated AIDS …

Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the herpesvirus family, has
evolved to establish a long-term, latent infection of cells such that while they carry the viral …

Kaposi's sarcoma-associated herpesvirus (KSHV) is a large double-stranded DNA
gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi's …

Cells infected by viruses utilize interferon (IFN)-mediated and p53-mediated irreversible cell
cycle arrest and apoptosis as part of the overall host surveillance mechanism to ultimately …

Upon viral infection, the major defensive strategy employed by the host immune system is
the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN …