Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Controversies in vitamin D: a statement from the third international conference

A Giustina, R Bouillon, N Binkley… - Journal of Bone and …, 2020 - academic.oup.com
Abstract The Third International Conference on Controversies in Vitamin D was held in
Gubbio, Italy, September 10–13, 2019. The conference was held as a follow up to previous …

The role of vitamin D in breast cancer risk and progression

J Vanhevel, L Verlinden, S Doms… - Endocrine-related …, 2022 - erc.bioscientifica.com
The active form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is primarily
known as a key regulator of calcium and phosphate homeostasis. It exerts its biological …

The effect of vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials

M Sepidarkish, F Farsi, M Akbari-Fakhrabadi… - Pharmacological …, 2019 - Elsevier
Recent studies have shown that vitamin D supplementation beneficially decreases oxidative
stress (OS) parameters; however, there is no consensus on this subject. In this systematic …

Ionizing radiation as a source of oxidative stress—the protective role of melatonin and vitamin D

J Nuszkiewicz, A Woźniak… - International journal of …, 2020 - mdpi.com
Ionizing radiation (IR) has found widespread application in modern medicine, including
medical imaging and radiotherapy. As a result, both patients and healthcare professionals …

1, 25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis

R Yang, J Chen, J Zhang, R Qin, R Wang, Y Qiu… - Aging …, 2020 - Wiley Online Library
Abstract To determine whether 1, 25‐dihydroxyvitamin D (1, 25 (OH) 2D) can exert an anti‐
osteoporosis role through anti‐aging mechanisms, we analyzed the bone phenotype of mice …

Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age

R Bouillon, L Antonio, OR Olarte - Nutrients, 2022 - mdpi.com
Vitamin D deficiency is the main cause of nutritional rickets in children and osteomalacia in
adults. There is consensus that nutritional access to vitamin D can be estimated by …

Health effects of vitamin D supplementation: lessons learned from randomized controlled trials and Mendelian randomization studies

R Bouillon, MS LeBoff, RE Neale - Journal of Bone and Mineral …, 2023 - academic.oup.com
Vitamin D plays an important role in calcium homeostasis and many cellular processes.
Although vitamin D supplements are widely recommended for community‐dwelling adults …

[HTML][HTML] Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies

D Song, Y Deng, K Liu, L Zhou, N Li, Y Zheng… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Epidemiological studies have indicated that blood vitamin D levels are linked to cancer.
Here we conducted a dose–response meta-analysis based on published observational …

Vitamin D and COVID‐19: A review on the role of vitamin D in preventing and reducing the severity of COVID‐19 infection

M Abdrabbo, CM Birch, M Brandt, KA Cicigoi… - Protein …, 2021 - Wiley Online Library
Abstract Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) is a
pathogenic coronavirus causing COVID‐19 infection. The interaction between the SARS …