Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are conditions that affect a
large number of people in the industrialized countries. Both conditions are on the increase …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Amyloid cross-seeding of different amyloid proteins is considered as a highly possible
mechanism for exacerbating the transmissible pathogenesis of protein misfolding disease …

Epidemiological studies have shown that the development of Alzheimer's disease (AD) is
associated with type 2 diabetes (T2D), but it still remains unclear how AD and T2D are …

In mammals, amylin (AMY) is a peptide that is secreted from the pancreas in response to a
meal. AMY inhibits food intake and may also contribute to the anorectic effects of the brain …

Pancreatic cancer is a devastating disease characterized by a dismal prognosis with most
patients dying within six months after diagnosis. Surgery is an option in less than one in five …

Abstract Aims/Hypothesis: Islet amyloid polypeptide (IAPP) reduces food intake and body
weight in laboratory animals. In addition, IAPP appears to regulate nutrient metabolism. In …

Objective: To characterize the interactive effects of amylin with phentermine or sibutramine
on food intake, body weight/composition and gene expression in diet-induced obese (DIO) …

The pancreatic peptide hormone amylin (AMY) and the AMY receptor agonist salmon
calcitonin (sCT) reduce short-term food intake in rats primarily by activating neurons located …