Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …

Arginine methylation is now coming out of the shadows of protein phosphorylation and
entering the mainstream, largely due to the identification of the family of enzymes that lay …

Fast-transmitting vertebrate axons are electrically insulated with multiple layers of
nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane …

The pathogenesis of MS is unknown. In our studies, we have demonstrated an important
role for citrullinated myelin basic protein (MBP). The accompanying loss of positive charge …

The 18.5 kDa isoform of myelin basic protein (MBP) is a major component of the myelin
sheath in the central nervous system of higher vertebrates, and a member of a larger family …

Modification of arginine residues by citrullination is catalyzed by peptidylarginine
deiminases (PADs), of which five are known, generating irreversible protein structural …

Central nervous system myelin is a dynamic entity arising from membrane processes
extended from oligodendrocytes, which form a tightly wrapped multilamellar structure …

Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines.
They are suspected to be involved in multiple sclerosis and rheumatoid arthritis …

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

Biological functions of proteins are influenced by posttranslational modifications such as
on/off switching by phosphorylation and modulation by glycosylation. Proteolytic processing …