Treatment landscape of triple-negative breast cancer—expanded options, evolving needs

G Bianchini, C De Angelis, L Licata… - Nature reviews Clinical …, 2022 - nature.com
Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …

[HTML][HTML] Triple‑negative breast cancer therapy: Current and future perspectives

KA Won, C Spruck - International journal of …, 2020 - … .spandidos-publications.com
Triple‑negative breast cancer (TNBC) accounts for 10‑15% of all breast cancer cases.
TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and …

[HTML][HTML] Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

F Yang, Y Xiao, JH Ding, X Jin, D Ma, DQ Li, JX Shi… - Cell metabolism, 2023 - cell.com
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

[HTML][HTML] Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

BD Lehmann, A Colaprico, TC Silva, J Chen… - Nature …, 2021 - nature.com
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …

[HTML][HTML] Recent advances in targeted strategies for triple-negative breast cancer

S Zhu, Y Wu, B Song, M Yi, Y Yan, Q Mei… - Journal of Hematology & …, 2023 - Springer
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …

[HTML][HTML] PI3K inhibitors in cancer: clinical implications and adverse effects

R Mishra, H Patel, S Alanazi, MK Kilroy… - International journal of …, 2021 - mdpi.com
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …

[HTML][HTML] Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications

K Asleh, N Riaz, TO Nielsen - Journal of Experimental & Clinical Cancer …, 2022 - Springer
As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …

Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?

X Bai, J Ni, J Beretov, P Graham, Y Li - Cancer letters, 2021 - Elsevier
Triple-negative breast cancer (TNBC) shows a higher response rate to systemic therapy
compared with other breast cancer subtypes. However, the tumor differentiation of TNBC is …

[HTML][HTML] Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments

U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Newly developed targeted therapies against the androgen receptor in triple-negative breast cancer: A review

E Choupani, MM Gomari, S Zanganeh, S Nasseri… - Pharmacological …, 2023 - ASPET
Among different types of breast cancers (BC), triple-negative BC (TNBC) amounts to 15% to
20% of breast malignancies. Three principal characteristics of TNBC cells are (i) extreme …