Treatment landscape of triple-negative breast cancer—expanded options, evolving needs
G Bianchini, C De Angelis, L Licata… - Nature reviews Clinical …, 2022 - nature.com
Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
[HTML][HTML] Triple‑negative breast cancer therapy: Current and future perspectives
KA Won, C Spruck - International journal of …, 2020 - … .spandidos-publications.com
Triple‑negative breast cancer (TNBC) accounts for 10‑15% of all breast cancer cases.
TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and …
TNBCs lack estrogen and progesterone receptors and express low levels of HER2, and …
[HTML][HTML] Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
F Yang, Y Xiao, JH Ding, X Jin, D Ma, DQ Li, JX Shi… - Cell metabolism, 2023 - cell.com
Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …
[HTML][HTML] Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …
characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs …
[HTML][HTML] Recent advances in targeted strategies for triple-negative breast cancer
S Zhu, Y Wu, B Song, M Yi, Y Yan, Q Mei… - Journal of Hematology & …, 2023 - Springer
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …
[HTML][HTML] PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
[HTML][HTML] Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …
Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?
Triple-negative breast cancer (TNBC) shows a higher response rate to systemic therapy
compared with other breast cancer subtypes. However, the tumor differentiation of TNBC is …
compared with other breast cancer subtypes. However, the tumor differentiation of TNBC is …
[HTML][HTML] Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments
U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …
million new cases in world in 2018. It is the second leading cause of death from cancer in …
Newly developed targeted therapies against the androgen receptor in triple-negative breast cancer: A review
Among different types of breast cancers (BC), triple-negative BC (TNBC) amounts to 15% to
20% of breast malignancies. Three principal characteristics of TNBC cells are (i) extreme …
20% of breast malignancies. Three principal characteristics of TNBC cells are (i) extreme …