Opioid-induced dysbiosis (OID) is a specific condition describing the consequences of
opioid use on the bacterial composition of the gut. Opioids have been shown to affect the …

The opioid G-protein coupled receptors (GPCRs) strongly modulate many of the central
nervous system structures that contribute to major neurological and psychiatric disorders …

Over the past three decades the United States has experienced a devastating opioid
epidemic. One of the many debilitating side effects of chronic opioid use is opioid-induced …

Ethnopharmacological relevance Chuanxiong, the rhizome of Ligusticum chuanxiong Hort.,
is an ancient herbal medicine that has gained extensive popularity in alleviating migraines …

Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and
antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 …

Migraine is a common brain-disorder that affects 15% of the population. Converging
evidence shows that migraine is associated with gastrointestinal disorders. However, the …

Objective To examine whether different classes of antibiotics in combination with opioids
differentially effect the risk of developing opioid use disorder (OUD). Methods A cohort study …

Amaç: Endo-opioid ve endo-kannabinoid sistemler ağrının regülasyonunda önemli rol oynar
ve migren fizyopatolojisi ile ilişkilendirilmişlerdir. Kronik migrende (KM) olduğu gibi sık atak …

In the past 50 years, scientists have made considerable strides toward understanding how
opioids act. This special issue of Molecular Pharmacology celebrates these 50 years of …

The gut microenvironment is a complex ecosystem that is modulated by alterations in i) the
gut microbiome, ii) the intestinal epithelial cell layer, and iii) the immune system. Opioid use …