A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Eukaryotic cells display a wide range of morphologies important for cellular function and
development. A particular cell shape is made via the generation of asymmetry in the …

Cells promote polarized growth by activation of Rho-family protein Cdc42 at the cell
membrane. We combined experiments and modeling to study bipolar growth initiation in …

Polarization is a fundamental cellular property, which is essential for the function of
numerous cell types. Over the past three to four decades, research using the best …

The small Rho-family GTPase Cdc42 is critical for cell polarization and polarizes
spontaneously in absence of upstream spatial cues. Spontaneous polarization is thought to …

For cell morphogenesis, the cell must establish distinct spatial domains at specified
locations at the cell surface. Here, we review the molecular mechanisms of cell polarity in …

Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas scaffold-
mediated positive feedback was proposed to break symmetry of budding yeast cells and …

Cells have developed protein quality-control strategies to manage the accumulation of
misfolded substrates during heat stress. Using a soluble reporter of misfolding in fission …

Pathogenic microorganisms must precisely regulate morphogenesis to survive and
proliferate within an infected host. This regulation is often controlled by conserved signal …

Protein kinases direct polarized growth by regulating the cytoskeleton in time and space and
could play similar roles in cell division. We found that the Cdc42-activated polarity kinase …