Spatial regulation of Cdc42 during cytokinesis
Cdc42 GTPase plays a critical role in the establishment of cell polarity in most eukaryotic
organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide …
organisms. Cdc42 active state, as that of other GTPases, depends on the bound nucleotide …
Conserved NDR/LATS kinase controls RAS GTPase activity to regulate cell growth and chronological lifespan
Adaptation to the nutritional environment is critical for all cells. RAS GTPase is a highly
conserved GTP-binding protein with crucial functions for cell growth and differentiation in …
conserved GTP-binding protein with crucial functions for cell growth and differentiation in …
[HTML][HTML] Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5
RNA-binding proteins contribute to the formation of ribonucleoprotein (RNP) granules by
phase transition, but regulatory mechanisms are not fully understood. Conserved fission …
phase transition, but regulatory mechanisms are not fully understood. Conserved fission …
[HTML][HTML] Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein
Rho GTPase-activating proteins (GAPs) are responsible for the inactivation of Rho GTPases,
which are involved in the regulation of critical biological responses in eukaryotic cells …
which are involved in the regulation of critical biological responses in eukaryotic cells …
Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast
UN Onwubiko, J Rich-Robinson, RA Mustaf… - Small GTPases, 2021 - Taylor & Francis
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum
synthesis followed by septum digestion resulting in cell separation. A recent report indicates …
synthesis followed by septum digestion resulting in cell separation. A recent report indicates …
The Tea4–PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion
K Kokkoris, D Gallo Castro… - Journal of cell …, 2014 - journals.biologists.com
Cell polarization relies on small GTPases, such as Cdc42, which can break symmetry
through self-organizing principles, and landmarks that define the axis of polarity. In fission …
through self-organizing principles, and landmarks that define the axis of polarity. In fission …
A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing
UN Onwubiko, PJ Mlynarczyk, B Wei… - Journal of cell …, 2019 - journals.biologists.com
During cytokinesis, fission yeast coordinates actomyosin ring constriction with septum
ingression, resulting in concentric furrow formation by a poorly defined mechanism. We …
ingression, resulting in concentric furrow formation by a poorly defined mechanism. We …
[HTML][HTML] The multiple functions of Rho GTPases in fission yeasts
The Rho family of GTPases represents highly conserved molecular switches involved in a
plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has …
plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has …
Hob3p, the fission yeast ortholog of human BIN3, localizes Cdc42p to the division site and regulates cytokinesis
Cdc42 GTPase is required for polarization in eukaryotic cells, but its spatial regulation is
poorly understood. In Schizosaccharomyces pombe, Cdc42p is activated by Scd1p and …
poorly understood. In Schizosaccharomyces pombe, Cdc42p is activated by Scd1p and …
F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe
BS Hercyk, ME Das - Genetics, 2019 - academic.oup.com
Abstract Cdc42, a Rho-family GTPase, is a master regulator of cell polarity. Recently, it has
been shown that Cdc42 also facilitates proper cytokinesis in the fission yeast …
been shown that Cdc42 also facilitates proper cytokinesis in the fission yeast …