The highly conserved small GTPase Cdc42 regulates polarized cell growth and
morphogenesis from yeast to humans. We previously reported that Cdc42 activation exhibits …

Articular cartilage is incapable of self-repair and any damage to the tissue results in
degradation leading to Osteoarthritis. To prevent Osteoarthritis progression, cell-based …

Cells undergo polarized growth to acquire shapes that promote function. In fission yeast,
polarized cell growth is driven by the Morphogenesis Orb6 (MOR) pathway and the small …

Cdc42 rules cell polarity and growth in fission yeast. It is negatively and positively regulated
by GTPase-activating proteins (GAPs) and by Guanine nucleotide Exchange factors (GEFs) …

Cells detect external chemical gradients and generate appropriate responses in a process
known as gradient sensing. Chemotaxis (directed movement) and chemotropism (directed …

In fission yeast, polarized cell growth stops during division and resumes after cell separation
at the end that existed in the previous generation. It is unclear how growth occurs specifically …

Abstract The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-
shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 …

Candida albicans is a fungal human pathogen that can cause life-threatening infections in
immunocompromised patients, in part, due to its ability to switch between an oval budding …

ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell
polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 …

The Rho family of GTPases represents highly conserved molecular switches involved in a
plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has …