Organ-on-a-chip platforms for drug screening and delivery in tumor cells: A systematic review

IM Gonçalves, V Carvalho, RO Rodrigues, D Pinho… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the diseases with a high mortality rate worldwide. Of the
current strategies to study new diagnostic and treating tools, organs-on-chip are quite …

Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening

F Castro, CL Pereira, MH Macedo, A Almeida… - Advanced Drug Delivery …, 2021 - Elsevier
Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated
with high mortality worldwide, exposing the urgent need for novel therapeutic approaches …

High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics

Z Zhu, S Li, D Wu, H Ren, C Ni, C Wang, N Xiang, Z Ni - Lab on a Chip, 2022 - pubs.rsc.org
Accurate and rapid diagnosis of malignant pleural and peritoneal effusions is critical due to
potential association with advanced disease stages or progression. Traditional …

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

T Petreus, E Cadogan, G Hughes, A Smith… - Communications …, 2021 - nature.com
Microphysiological in vitro systems are platforms for preclinical evaluation of drug effects
and significant advances have been made in recent years. However, existing microfluidic …

[HTML][HTML] The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: A review

V Carvalho, M Bañobre-López, G Minas, SFCF Teixeira… - Bioprinting, 2022 - Elsevier
Every year, cancer causes millions of deaths around the globe, and researchers have been
engaged to provide novel therapies for this threatening disease. However, this process is …

Generation of flow and droplets with an ultra-long-range linear concentration gradient

B Dai, Y Long, J Wu, S Huang, Y Zhao, L Zheng… - Lab on a Chip, 2021 - pubs.rsc.org
In the chemical and biological fields, the creation of concentration gradient
microenvironments is an important approach for many applications, such as crystal growth …

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease

J Liu, R Lu, X Zheng, W Hou, X Wu, H Zhao… - Biomaterials …, 2023 - pubs.rsc.org
Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and
treatment of inflammatory bowel disease (IBD), but the progression and mechanisms are …

Microfluidic dose–response platform to track the dynamics of drug response in single mycobacterial cells

M Mistretta, N Gangneux, G Manina - Scientific Reports, 2022 - nature.com
Preclinical analysis of drug efficacy is critical for drug development. However, conventional
bulk-cell assays statically assess the mean population behavior, lacking resolution on drug …

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

D Singh, SP Deosarkar, E Cadogan, V Flemington… - Plos …, 2022 - journals.plos.org
Test compounds used on in vitro model systems are conventionally delivered to cell culture
wells as fixed concentration bolus doses; however, this poorly replicates the …

Mimicking and surpassing the xenograft model with cancer-on-chip technology

J Komen, SM van Neerven, A van den Berg… - …, 2021 - thelancet.com
Organs-on-chips are in vitro models in which human tissues are cultured in microfluidic
compartments with a controlled, dynamic micro-environment. Specific organs-on-chips are …