Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Diabetic cardiomyopathy: a hyperglycaemia-and insulin-resistance-induced heart disease

G Jia, A Whaley-Connell, JR Sowers - Diabetologia, 2018 - Springer
Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation
abnormalities and later by clinical heart failure in the absence of dyslipidaemia …

Role of oxidative stress in diabetic cardiomyopathy

B De Geest, M Mishra - Antioxidants, 2022 - mdpi.com
Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

M Knapp, X Tu, R Wu - Acta Pharmacologica Sinica, 2019 - nature.com
Diabetes mellitus is currently a major public health problem. A common complication of
diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads …

Diabetic cardiomyopathy: does the type of diabetes matter?

ME Hölscher, C Bode, H Bugger - International journal of molecular …, 2016 - mdpi.com
In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that
parallels the increased prevalence of obesity and which markedly increases the risk of …

Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications

ZY Fang, JB Prins, TH Marwick - Endocrine reviews, 2004 - academic.oup.com
The presence of a diabetic cardiomyopathy, independent of hypertension and coronary
artery disease, is still controversial. This systematic review seeks to evaluate the evidence …

Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment

I Falcão-Pires, AF Leite-Moreira - Heart failure reviews, 2012 - Springer
Diabetes mellitus is an important and prevalent risk factor for congestive heart failure.
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …

Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes

D Aronson - Journal of hypertension, 2003 - journals.lww.com
The normal aging process is often accompanied by arterial wall stiffening and by a decrease
in myocardial compliance. These processes contribute to isolated systolic hypertension and …

Diastolic dysfunction in normotensive men well-controlled type 2 diabetes

P Poirier, P Bogaty, C Garneau, L Marois… - Clinical …, 2001 - journals.viamedica.pl
OBJECTIVE. Because a pseudonormal pattern of ventricular filling has never been
considered in studies that reported a prevalence of left ventricular diastolic dysfunction …

Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function

KJ Nadeau, JG Regensteiner, TA Bauer… - The Journal of …, 2010 - academic.oup.com
Context: Cardiovascular disease is the major cause of death in adults with diabetes, yet little
is specifically known about the effects of type 1 diabetes (T1D) on cardiovascular outcomes …