The impact of pre-existing comorbidities and therapeutic interventions on COVID-19

LA Callender, M Curran, SM Bates… - Frontiers in …, 2020 - frontiersin.org
Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …

Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations

JM Albandar, C Susin… - Journal of clinical …, 2018 - Wiley Online Library
Objectives This review proposes case definitions and diagnostic considerations of systemic
disorders and conditions that affect the periodontal attachment apparatus. Importance …

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients …

L Palaiodimos, DG Kokkinidis, W Li, D Karamanis… - Metabolism, 2020 - Elsevier
Abstract Background & aims New York is the current epicenter of Coronavirus disease 2019
(COVID-19) pandemic. The underrepresented minorities, where the prevalence of obesity is …

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

CA Thaiss, M Levy, I Grosheva, D Zheng, E Soffer… - Science, 2018 - science.org
Obesity, diabetes, and related manifestations are associated with an enhanced, but poorly
understood, risk for mucosal infection and systemic inflammation. Here, we show in mouse …

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

X Michelet, L Dyck, A Hogan, RM Loftus… - Nature …, 2018 - nature.com
Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms
include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells …

Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

The influence of the gut microbiome on host metabolism through the regulation of gut hormone release

AM Martin, EW Sun, GB Rogers, DJ Keating - Frontiers in physiology, 2019 - frontiersin.org
The microbial community of the gut conveys significant benefits to host physiology. A clear
relationship has now been established between gut bacteria and host metabolism in which …

The association of periodontal diseases with metabolic syndrome and obesity

S Jepsen, J Suvan, J Deschner - Periodontology 2000, 2020 - Wiley Online Library
Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic
plaque biofilms and characterized by progressive destruction of the toothsupporting …

Arachidonic acid metabolites in cardiovascular and metabolic diseases

T Sonnweber, A Pizzini, M Nairz, G Weiss… - International journal of …, 2018 - mdpi.com
Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

LM Frydrych, G Bian, DE O'Lone… - Journal of leukocyte …, 2018 - academic.oup.com
Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the
prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D has almost …